Common Name: Albendazole Suspension

 

Main Components: Albendazole

 

Character:

This product is a fine particle suspension solution, fine particle will be precipitation after standing, and it will be into white or white uniform suspension after shaking.

 

Pharmacological Action:

Albendazole has broad-spectrum anthelmintic action, nematode is sensitive to it. It also has a stronger effect in tapeworm and trematode. Its mechanism of action is to prevent it combine with α-tubulin to be multimeric to composite microtubules by combining with β-tubulin in elegans body. Thus, it can affect cell reproduction process in elegans body, which includes mitosis, protein assembly and energy metabolism etc. This product has not only strong effect on adult worms, but also has strong effect on immature worms and larvae and has efficiency of killing the worms’ eggs. Albendazole’s affinity on tubulin of nematodes is significantly higher than the affinity on tubulin of mammals, so Its toxicity is very small on mammalian.

Ivermectin has good repelling and killing effect in external parasite, nematode in vivo and arthropod. The anthelmintic action mechanism lies in promoting the presynaptic neuron releasing gamma aminobutyric acid (GABA), thus opening the chloride ion channel mediated by GABA. Ivermectin has selectivity and high affinity to chloride channel mediated by glutamate which is near the GABA mediated site of invertebrate nerve and muscle cells, Thus interfere with neuromuscular signal transmission, makes the insect body to be flabby and paralytic to lead to parasite to be death or discharged in vitro.

 

Indication:

It is used in the treatment of nematode, taeniasis and fluke disease of livestock and poultry.

 

Dosage and Administration:

For oral administration

Horse: 5-10 mg per each kg of body weight, one time

Cattle, Sheep: 10-15 mg per each kg of body weight, one time

Swine: 5-10 mg per each kg of body weight, one time

Dog: 25-50 mg per each kg of body weight, one time

Poultry: 10-20 mg per each kg of body weight, one time

 

Adverse Reaction:

When albendazole is used in animal use during the first trimester of pregnancy, which may be associated with teratogenicity and embryotoxicity effect.

 

Precautions:

1. Lactation cows are prohibited.

2. Female livestock should be with caution in the early 45 days of the pregnancy

3. Ivermectin in this product is highly toxic to fish, shrimp, remnants, packaging products and animal waste do not pollute the water.

 

Storage: 

Sealed. Keep in a cool and dry place away from light.